THRAP3

THRAP3 (Thyroid Hormone Receptor Associated Protein 3) is a Protein Coding gene. Diseases related to THRAP3 include Wilms Tumor 1. Among its related pathways are PEDF Induced Signaling and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Gene Ontology (GO) annotations related to THRAP3 include transcription coactivator activity. An important paralog of THRAP3 is BCLAF1.

Full Name

Thyroid Hormone Receptor Associated Protein 3

Function

Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-ARNTL/BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes (PubMed:24043798).

Biological Process

Biological Process circadian rhythmSource:Ensembl
Biological Process mRNA processingSource:UniProtKB-KW
Biological Process mRNA stabilizationSource:UniProtKB1 Publication
Biological Process nuclear-transcribed mRNA catabolic processSource:UniProtKB1 Publication
Biological Process positive regulation of circadian rhythmSource:UniProtKB1 Publication
Biological Process positive regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process positive regulation of mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:MGI1 Publication
Biological Process regulation of alternative mRNA splicing, via spliceosomeSource:UniProtKB1 Publication
Biological Process RNA splicingSource:UniProtKB-KW

Cellular Location

Nucleus
Nucleus, nucleoplasm
Nucleus speckle

PTM

ADP-ribosylation during genotoxic stress promotes accumulation in nuclear speckles.