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Rat Anti-Timd2 Recombinant Antibody (CBYJT-3148) (CBMAB-T2419-YJ)

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Basic Information

Host Animal
Rat
Clone
CBYJT-3148
Application
WB
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TIM-2, His22-Asn229, Accession # NP_599010
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 22-229
More Infomation

Target

Full Name
T Cell Immunoglobulin And Mucin Domain Containing 2
Introduction
Timd2 is a probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.
Entrez Gene ID
171284
UniProt ID
Q8R183
Alternative Names
G9D3; Tim2; TIM-2; C78111; AA816106; AU019358; AU019662
Function
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Biological Process
Biological Process iron ion transportSource:MGI1 Publication
Biological Process phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process positive regulation of mast cell activationSource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-231
Helical: 232-252
Cytoplasmic: 253-305
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

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Rat Anti-Timd2 Recombinant Antibody (CBYJT-3147) (CAT#: CBMAB-T2418-YJ)

Mouse Anti-Timd2 Recombinant Antibody (CBYJT-3149) (CAT#: CBMAB-T2421-YJ)

Rat Anti-Timd2 Recombinant Antibody (CBYJT-3151) (CAT#: CBMAB-T2423-YJ)

Isotype control

For research use only. Not intended for any clinical use.

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