Timd2

Timd2 is a probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.
Full Name
T Cell Immunoglobulin And Mucin Domain Containing 2
Function
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Biological Process
Biological Process iron ion transportSource:MGI1 Publication
Biological Process phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process positive regulation of mast cell activationSource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-231
Helical: 232-252
Cytoplasmic: 253-305
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Anti-Timd2 antibodies

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Rat Anti-Timd2 Recombinant Antibody (CBYJT-3151) (CBMAB-T2423-YJ)

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Target: Timd2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3151
Application*: F, IP, WB
Datasheet SDS

Rat Anti-Timd2 Recombinant Antibody (CBYJT-3150) (CBMAB-T2422-YJ)

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Target: Timd2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3150
Application*: WB
Datasheet SDS

Mouse Anti-Timd2 Recombinant Antibody (CBYJT-3149) (CBMAB-T2421-YJ)

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Target: Timd2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYJT-3149
Application*: F
Datasheet SDS

Rat Anti-Timd2 Recombinant Antibody (CBYJT-3148) (CBMAB-T2419-YJ)

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Target: Timd2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3148
Application*: WB
Datasheet SDS

Rat Anti-Timd2 Recombinant Antibody (CBYJT-3147) (CBMAB-T2418-YJ)

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Target: Timd2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3147
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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