Timd2
Timd2 is a probable receptor for SEMA4A involved in the regulation of T-cell function. The interaction with SEMA4A enhances T-cell activation.
Full Name
T Cell Immunoglobulin And Mucin Domain Containing 2
Function
Cell surface glycoprotein that participates in iron homeostasis in the liver, the kidney, the retina and oligodendrocytes by acting as a receptor of H-ferritin (PubMed:16203866, PubMed:33065090).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Mechanistically, mediates iron-containing ferritin uptake via an endocytic pathway, trafficking to endosomes and subsequently to lysosomes (PubMed:16043519, PubMed:21886823).
Plays also an important role in the regulation of Th2 immunity (PubMed:16043519).
Receptor for SEMA4A involved in the regulation of T-cell function, enhancing T-cell activation (PubMed:12374982).
Biological Process
Biological Process iron ion transportSource:MGI1 Publication
Biological Process phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process positive regulation of mast cell activationSource:GO_Central1 Publication
Biological Process phagocytosis, engulfmentSource:GO_Central1 Publication
Biological Process positive regulation of mast cell activationSource:GO_Central1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 22-231
Helical: 232-252
Cytoplasmic: 253-305
Helical: 232-252
Cytoplasmic: 253-305
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Anti-Timd2 antibodies
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Target: Timd2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3151
Application*: F, IP, WB
Target: Timd2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3150
Application*: WB
Target: Timd2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYJT-3149
Application*: F
Target: Timd2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYJT-3148
Application*: WB
Target: Timd2
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3147
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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