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Mouse Anti-TIMP3 Recombinant Antibody (136-13H4) (CBMAB-T2497-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIMP3 (TIMP Metallopeptidase Inhibitor 3). The antibody can be used for immunoassay techniques, such as WB.
See all TIMP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
136-13H4
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
TIMP3 antibody was raised in mouse using a sythetic peptide corresponding to amino acid residues 170-188 of human TIMP-3 as the immunogen
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 100 μg BSA
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 170-188

Target

Full Name
TIMP3 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 3
Introduction
TIMP3 belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of TIMP3 is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in TIMP3 have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Entrez Gene ID
7078
UniProt ID
P35625
Alternative Names
TIMP Metallopeptidase Inhibitor 3; Tissue Inhibitor Of Metalloproteinases 3; Protein MIG-5; TIMP-3; Tissue Inhibitor Of Metalloproteinase 3 (Sorsby Fundus Dystrophy, Pseudoinflammatory); Metalloproteinase Inhibitor 3
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Biological Process
Biological Process cellular response to organic substanceSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of ERK1 and ERK2 cascadeSource:BHF-UCL1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of metalloendopeptidase activitySource:BHF-UCL
Biological Process positive regulation of TRAIL-activated apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process visual perceptionSource:UniProtKB-KW
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Sorsby fundus dystrophy (SFD):
Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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