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Mouse Anti-TIMP3 Recombinant Antibody (CBXS-0930) (CBMAB-S3844-CQ)

This product is a mouse antibody that recognizes TIMP3. The antibody CBXS-0930 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA.
See all TIMP3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0930
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Tissue Inhibitors Of Metalloproteinase 3
Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMP3 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 3
Introduction
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Entrez Gene ID
7078
UniProt ID
P35625
Alternative Names
TIMP Metallopeptidase Inhibitor 3; Tissue Inhibitor Of Metalloproteinases 3; Protein MIG-5; TIMP-3; Tissue Inhibitor Of Metalloproteinase 3 (Sorsby Fundus Dystrophy, Pseudoinflammatory); Metalloproteinase Inhibitor 3;
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
Biological Process
Biological Process cellular response to organic substanceSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of ERK1 and ERK2 cascadeSource:BHF-UCL1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of metalloendopeptidase activitySource:BHF-UCL
Biological Process positive regulation of TRAIL-activated apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process visual perceptionSource:UniProtKB-KW
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Sorsby fundus dystrophy (SFD):
Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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