Mouse Anti-TIMP3 Recombinant Antibody (CBYJT-3225) (CBMAB-T2505-YJ)

Name: Mouse Anti-TIMP3 Recombinant Antibody (CBYJT-3225)
SKU: CBMAB-T2505-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3225

Application

IHC, WB

Immunogen

Oligopeptide corresponding to aa170-188, SWYRGWAPPDKSIINATDP on human Tissue Inhibitor of Metalloproteinases 3. Sequence homology: rat (18/19)

Specificity

Human, Rabbit

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.0, 2% BSA

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 170-188

More Infomation

Target

Full Name

TIMP3 Gene(Protein Coding) TIMP Metallopeptidase Inhibitor 3

Introduction

TIMP3 belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of TIMP3 is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in TIMP3 have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.

Entrez Gene ID

Human	7078
Rabbit	100008690

UniProt ID

Human	P35625
Rabbit	O97590

Alternative Names

TIMP Metallopeptidase Inhibitor 3; Tissue Inhibitor Of Metalloproteinases 3; Protein MIG-5; TIMP-3; Tissue Inhibitor Of Metalloproteinase 3 (Sorsby Fundus Dystrophy, Pseudoinflammatory); Metalloproteinase Inhibitor 3

Function

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Biological Process

Biological Process cellular response to organic substanceSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of ERK1 and ERK2 cascadeSource:BHF-UCL1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:BHF-UCL1 Publication
Biological Process negative regulation of metalloendopeptidase activitySource:BHF-UCL
Biological Process positive regulation of TRAIL-activated apoptotic signaling pathwaySource:BHF-UCL1 Publication
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process visual perceptionSource:UniProtKB-KW

Cellular Location

Secreted, extracellular space, extracellular matrix

Involvement in disease

Sorsby fundus dystrophy (SFD):
Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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