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Mouse Anti-TIMP4 Recombinant Antibody (9:4-7) (CBMAB-T2514-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIMP4 (TIMP Metallopeptidase Inhibitor 4). The antibody can be used for immunoassay techniques, such as WB, ELISA, IHC, IHC-P.
See all TIMP4 antibodies
Published Data
Fig.1 Test for reactivity in immunohistochemical staining of FFPE breast tissue.
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Fig.2 Native-PAGE analysis of TIMP-4 mAb.
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Fig.3 TIMP-4 immunohistochemical staining of human tissues.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
9:4-7
Antibody Isotype
IgG2b, κ
Application
WB, ELISA, IHC, IHC-P

Basic Information

Immunogen
Full length human TIMP4 protein. Protein accession number NM_003256.3
Specificity
Human, Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TIMP Metallopeptidase Inhibitor 4
Introduction
TIMP4 belongs to the TIMP gene family. The proteins encoded by TIMP4 family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by TIMP4 is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Entrez Gene ID
Human7079
Mouse110595
UniProt ID
HumanQ99727
MouseQ9JHB3
Alternative Names
TIMP Metallopeptidase Inhibitor 4; Tissue Inhibitor Of Metalloproteinases 4; Tissue Inhibitor Of Metalloproteinase 4; TIMP-4; Metalloproteinase Inhibitor 4
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Biological Process
Biological Process central nervous system developmentSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process ovulation cycleSource:Ensembl
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Biological Process response to xenobiotic stimulusSource:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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