TIMP4

TIMP4 belongs to the TIMP gene family. The proteins encoded by TIMP4 family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by TIMP4 is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.

TIMP Metallopeptidase Inhibitor 4

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.

Biological Process central nervous system developmentSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process ovulation cycleSource:Ensembl
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Biological Process response to xenobiotic stimulusSource:Ensembl

Secreted