TIMP4
TIMP4 belongs to the TIMP gene family. The proteins encoded by TIMP4 family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by TIMP4 is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Full Name
TIMP Metallopeptidase Inhibitor 4
Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Biological Process
Biological Process central nervous system developmentSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process ovulation cycleSource:Ensembl
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Biological Process response to xenobiotic stimulusSource:Ensembl
Biological Process negative regulation of endopeptidase activitySource:GO_Central1 Publication
Biological Process negative regulation of membrane protein ectodomain proteolysisSource:GO_Central1 Publication
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process ovulation cycleSource:Ensembl
Biological Process response to cytokineSource:GO_Central1 Publication
Biological Process response to hormoneSource:GO_Central1 Publication
Biological Process response to lipopolysaccharideSource:Ensembl
Biological Process response to organic substanceSource:GO_Central1 Publication
Biological Process response to peptide hormoneSource:Ensembl
Biological Process response to xenobiotic stimulusSource:Ensembl
Cellular Location
Secreted
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Anti-TIMP4 antibodies
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CompareTarget: TIMP4
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse
Clone: 9:4-7
Application*: WB, E, IH, P
Target: TIMP4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3227
Application*: E, F, IC, IF, WB
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: SB30c
Application*: WB, IH, IC, IF, C
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3232
Application*: WB, IH, P
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3231
Application*: IH, WB
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3230
Application*: IH, WB
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3229
Application*: WB, IH, EC
Target: TIMP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3228
Application*: IH, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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