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Mouse Anti-TINF2 Recombinant Antibody (59B388.1) (CBMAB-T2519-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TINF2 (TERF1 Interacting Nuclear Factor 2). The antibody can be used for immunoassay techniques, such as WB, ICC, IF, GS.
See all TINF2 antibodies
Published Data
Fig.1 Telomeric localization of TIN2 examined by immunofluorescence-FISH analysis in cells carrying heterozygous TIN2 mutation.
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Fig.2 Western analysis of TRF2, TRF1, POT1, TIN2, hRap1, and TPP1 in control, LMNA and WRN mutant primary fibroblasts.
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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
59B388.1
Antibody Isotype
IgG1
Application
WB, ICC, IF, GS

Basic Information

Immunogen
A synthetic peptide corresponding to amino acids 44-58 of human Tin2 was used as immunogen (NP_036593.2 )
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 44-58

Target

Full Name
TERF1 (TRF1)-interacting nuclear factor 2
Introduction
TINF2 is one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. TINF2 is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.
Entrez Gene ID
Human26277
Mouse28113
UniProt ID
HumanQ9BSI4
MouseQ9QXG9
Alternative Names
TERF1 Interacting Nuclear Factor 2; TERF1 (TRF1)-Interacting Nuclear Factor 2; TRF1-Interacting Nuclear Protein 2; TIN2; TERF1-Interacting Nuclear Factor 2; DKCA3
Function
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Biological Process
Biological Process negative regulation of epithelial cell proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of protein ADP-ribosylationSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenance via telomeraseSource:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenanceSource:ComplexPortal1 Publication
Biological Process protein localization to chromosome, telomeric regionSource:CACAO1 Publication
Biological Process regulation of telomere maintenance via telomere lengtheningSource:BHF-UCL1 Publication
Biological Process telomere assemblySource:BHF-UCL1 Publication
Biological Process telomere cappingSource:ComplexPortal1 Publication
Cellular Location
Nucleus
Chromosome, telomere
Associated with telomeres.
Isoform 1
Nucleus matrix
Involvement in disease
Dyskeratosis congenita, autosomal dominant, 3 (DKCA3):
A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
Dyskeratosis congenita, autosomal dominant, 5 (DKCA5):
A disease characterized by bone marrow hypoplasia, nail dystrophy, fine sparse hair, fine reticulate skin pigmentation, oral leukoplakia, bilateral exudative retinopathy, cerebellar hypoplasia, and growth retardation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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