Mouse Anti-TINF2 Recombinant Antibody (59B388.1) (CBMAB-T2519-YJ)

Name: Mouse Anti-TINF2 Recombinant Antibody (59B388.1)
SKU: CBMAB-T2519-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

59B388.1

Application

WB, ICC, IF, GS

Immunogen

A synthetic peptide corresponding to amino acids 44-58 of human Tin2 was used as immunogen (NP_036593.2 )

Specificity

Human, Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.4

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 44-58

More Infomation

Target

Full Name

TERF1 (TRF1)-interacting nuclear factor 2

Introduction

TINF2 is one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. TINF2 is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome.

Entrez Gene ID

Human	26277
Mouse	28113

UniProt ID

Human	Q9BSI4
Mouse	Q9QXG9

Alternative Names

TERF1 Interacting Nuclear Factor 2; TERF1 (TRF1)-Interacting Nuclear Factor 2; TRF1-Interacting Nuclear Protein 2; TIN2; TERF1-Interacting Nuclear Factor 2; DKCA3

Function

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.

Biological Process

Biological Process negative regulation of epithelial cell proliferationSource:BHF-UCL1 Publication
Biological Process negative regulation of protein ADP-ribosylationSource:BHF-UCL1 Publication
Biological Process negative regulation of telomere maintenance via telomeraseSource:BHF-UCL1 Publication
Biological Process positive regulation of telomere maintenanceSource:ComplexPortal1 Publication
Biological Process protein localization to chromosome, telomeric regionSource:CACAO1 Publication
Biological Process regulation of telomere maintenance via telomere lengtheningSource:BHF-UCL1 Publication
Biological Process telomere assemblySource:BHF-UCL1 Publication
Biological Process telomere cappingSource:ComplexPortal1 Publication

Cellular Location

Nucleus
Chromosome, telomere
Associated with telomeres.
Isoform 1
Nucleus matrix

Involvement in disease

Dyskeratosis congenita, autosomal dominant, 3 (DKCA3):
A rare multisystem disorder caused by defective telomere maintenance. It is characterized by progressive bone marrow failure, and the clinical triad of reticulated skin hyperpigmentation, nail dystrophy, and mucosal leukoplakia. Common but variable features include premature graying, aplastic anemia, low platelets, osteoporosis, pulmonary fibrosis, and liver fibrosis among others. Early mortality is often associated with bone marrow failure, infections, fatal pulmonary complications, or malignancy.
Dyskeratosis congenita, autosomal dominant, 5 (DKCA5):
A disease characterized by bone marrow hypoplasia, nail dystrophy, fine sparse hair, fine reticulate skin pigmentation, oral leukoplakia, bilateral exudative retinopathy, cerebellar hypoplasia, and growth retardation.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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