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Mouse Anti-TIPRL Recombinant Antibody (CBYJT-3248) (CBMAB-T2531-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TIPRL (TOR Signaling Pathway Regulator). The antibody can be used for immunoassay techniques, such as WB, FC, IHC, IHC-P.
See all TIPRL antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3248
Antibody Isotype
IgG1
Application
WB, FC, IHC, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human TIPRL (NP_690866) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TOR Signaling Pathway Regulator
Introduction
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).
Entrez Gene ID
261726
UniProt ID
O75663
Alternative Names
TOR Signaling Pathway Regulator; Putative MAPK-Activating Protein PM10; Type 2A-Interacting Protein; TIP; TIP41, TOR Signaling Pathway Regulator-Like (S. Cerevisiae); TIP41, TOR Signaling Pathway Regulator-Like; TIP41-Like Protein; TIPRL1; TIP41
Function
May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Biological Process
Biological Process DNA damage checkpoint signalingSource:UniProtKB1 Publication
Biological Process negative regulation of phosphoprotein phosphatase activitySource:UniProtKB1 Publication
Biological Process regulation of phosphoprotein phosphatase activitySource:GO_Central1 Publication
Biological Process TOR signalingSource:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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