TIPRL

TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).

Full Name

TOR Signaling Pathway Regulator

Function

May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.

Biological Process

Biological Process DNA damage checkpoint signalingSource:UniProtKB1 Publication
Biological Process negative regulation of phosphoprotein phosphatase activitySource:UniProtKB1 Publication
Biological Process regulation of phosphoprotein phosphatase activitySource:GO_Central1 Publication
Biological Process TOR signalingSource:GO_Central1 Publication

Cellular Location

Cytoplasm