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Rabbit Anti-TLE1 Recombinant Antibody (CBYJT-3289) (CBMAB-T2576-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to TLE1 (Transducin Like Enhancer Of Split 1). The antibody can be used for immunoassay techniques, such as WB, IHC-P, ICC, IF.
See all TLE1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYJT-3289
Antibody Isotype
IgG
Application
WB, IHC-P, ICC, IF

Basic Information

Immunogen
Synthetic peptide within Human TLE 1 aa 200-300. The exact sequence is proprietary.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 200-300

Target

Full Name
TLE1 Transducin Like Enhancer Of Split 1
Introduction
TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases related to TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to TLE1 include identical protein binding and transcription factor binding. An important paralog of TLE1 is TLE4.
Entrez Gene ID
Human7088
Mouse21885
Rat362533
UniProt ID
HumanQ04724
MouseQ62440
RatD3ZCM7
Alternative Names
Transducin Like Enhancer Of Split 1; Transducin-Like Enhancer Of Split 1 (E(Sp1) Homolog, Drosophila); Enhancer Of Split Groucho-Like Protein 1; ESG1; Transducin-Like Enhancer Protein 1; Enhancer Of Split Groucho 1; E(Sp1) Homolog; GRG1; ESG
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity).
The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of anoikisSource:UniProtKB2 Publications
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process negative regulation of Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
PTM
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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