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TLE1

TLE1 (Transducin Like Enhancer Of Split 1) is a Protein Coding gene. Diseases associated with TLE1 include Synovium Cancer and Core Binding Factor Acute Myeloid Leukemia. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation and Signaling by NOTCH1. Gene Ontology (GO) annotations related to this gene include identical protein binding and transcription factor binding. An important paralog of this gene is TLE4.
Full Name
TLE1 Transducin Like Enhancer Of Split 1
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity).
The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Biological Process
Biological Process animal organ morphogenesisSource:ProtInc1 Publication
Biological Process negative regulation of anoikisSource:UniProtKB2 Publications
Biological Process negative regulation of canonical Wnt signaling pathwaySource:GO_Central1 Publication
Biological Process negative regulation of DNA-templated transcriptionSource:UniProtKB1 Publication
Biological Process negative regulation of I-kappaB kinase/NF-kappaB signalingSource:UniProtKB1 Publication
Biological Process negative regulation of Wnt signaling pathwaySource:UniProtKB1 Publication
Biological Process positive regulation of gene expressionSource:UniProtKB1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process Wnt signaling pathwaySource:UniProtKB-KW
Cellular Location
Nucleus
Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
PTM
Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.
Ubiquitinated by XIAP/BIRC4.
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Anti-TLE1 antibodies

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Mouse Anti-TLE1 Recombinant Antibody (CF440) (CBMAB-FT091LY)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF440
Application*: ELISA, WB, IHC
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (IHC676) (CBMAB-MA247-YC)

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Target: TLE1
Host: Mouse
Specificity: Human
Clone: IHC676
Application*: IH
Datasheet SDS

Mouse Anti-Tle1 Recombinant Antibody (CBYJT-3291) (CBMAB-T2578-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-3291
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-Tle1 Recombinant Antibody (CBYJT-3290) (CBMAB-T2577-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG
Specificity: Mouse, Rat, Human
Clone: CBYJT-3290
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-TLE1 Recombinant Antibody (CBYJT-3289) (CBMAB-T2576-YJ)

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Target: TLE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYJT-3289
Application*: WB, P, IC, IF
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3288) (CBMAB-T2575-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3288
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3287) (CBMAB-T2574-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3287
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (381CT18.5.1) (CBMAB-T2573-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 381CT18.5.1
Application*: E, WB
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3286) (CBMAB-T2572-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3286
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3285) (CBMAB-T2571-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3285
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3284) (CBMAB-T2570-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYJT-3284
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3283) (CBMAB-T2569-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3283
Application*: WB, P, F, IC, IF
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3282) (CBMAB-T2568-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3282
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-TLE1 Recombinant Antibody (CBYJT-3281) (CBMAB-T2567-YJ)

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Target: TLE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3281
Application*: WB, IH
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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