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Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3304) (CBMAB-T2592-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLK1 (Tousled Like Kinase 1). The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all TLK1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3304
Antibody Isotype
IgG3, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tousled-like kinase 1
Introduction
TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. TLK1 is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of it is diminished by DNA damage and by blockage of DNA replication.
Entrez Gene ID
9874
UniProt ID
Q9UKI8
Alternative Names
Tousled Like Kinase 1; Tousled-Like Kinase 1; EC 2.7.11.1; PKU-Beta; Serine/Threonine-Protein Kinase Tousled-Like 1; Serine Threonine Protein Kinase; SNARE Protein Kinase SNAK; EC 2.7.11; KIAA0137
Function
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB-KW
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:GO_Central1 Publication
Biological Process intracellular protein transportSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:GO_Central1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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