Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3304) (CBMAB-T2592-YJ)

Name: Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3304)
SKU: CBMAB-T2592-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3304

Application

ELISA, IHC-P, WB

Specificity

Human

Antibody Isotype

IgG3, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

tousled-like kinase 1

Introduction

TLK1 is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. TLK1 is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of it is diminished by DNA damage and by blockage of DNA replication.

Entrez Gene ID

9874

UniProt ID

Q9UKI8

Alternative Names

Tousled Like Kinase 1; Tousled-Like Kinase 1; EC 2.7.11.1; PKU-Beta; Serine/Threonine-Protein Kinase Tousled-Like 1; Serine Threonine Protein Kinase; SNARE Protein Kinase SNAK; EC 2.7.11; KIAA0137

Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB-KW
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:GO_Central1 Publication
Biological Process intracellular protein transportSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:GO_Central1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication

Cellular Location

Nucleus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-TLK1 Recombinant Antibody (4B3) (CAT#: CBMAB-A9133-LY)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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