TLK1

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM
Full Name
tousled-like kinase 1
Function
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
Biological Process
Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB-KW
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:GO_Central1 Publication
Biological Process intracellular protein transportSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:GO_Central1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication
Cellular Location
Nucleus
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Anti-TLK1 antibodies

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Mouse Anti-TLK1 Recombinant Antibody (4B3) (CBMAB-A9133-LY)

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Target: TLK1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4B3
Application*: WB, E
Datasheet SDS

Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3305) (CBMAB-T2593-YJ)

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Target: TLK1
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-3305
Application*: WB
Datasheet SDS

Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3304) (CBMAB-T2592-YJ)

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Target: TLK1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3304
Application*: E, P, WB
Datasheet SDS

Rabbit Anti-TLK1 Recombinant Antibody (CBYJT-3303) (CBMAB-T2591-YJ)

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Target: TLK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3303
Application*: WB, IP, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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