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TLK1

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.[supplied by OMIM

Full Name

tousled-like kinase 1

Function

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Biological Process

Biological Process cell cycleSource:UniProtKB-KW
Biological Process cellular response to DNA damage stimulusSource:UniProtKB-KW
Biological Process chromatin organizationSource:UniProtKB-KW
Biological Process chromosome segregationSource:GO_Central1 Publication
Biological Process intracellular protein transportSource:UniProtKB1 Publication
Biological Process intracellular signal transductionSource:UniProtKB1 Publication
Biological Process peptidyl-serine phosphorylationSource:GO_Central1 Publication
Biological Process protein phosphorylationSource:UniProtKB1 Publication
Biological Process regulation of chromatin organizationSource:UniProtKB1 Publication

Cellular Location

Nucleus

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Anti-TLK1 antibodies

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Mouse Anti-TLK1 Recombinant Antibody (4B3) (CBMAB-A9133-LY)

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Target: TLK1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 4B3

Application*: WB, E

Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3305) (CBMAB-T2593-YJ)

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Target: TLK1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBYJT-3305

Application*: WB

Mouse Anti-TLK1 Recombinant Antibody (CBYJT-3304) (CBMAB-T2592-YJ)

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Target: TLK1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBYJT-3304

Application*: E, P, WB

Rabbit Anti-TLK1 Recombinant Antibody (CBYJT-3303) (CBMAB-T2591-YJ)

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Target: TLK1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3303

Application*: WB, IP, F

Human Recombinant TLK1 protein, GST Tag (V2LY-0526-LY7263)

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Target: TLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: 1-766

Tag: GST Tag

Human Recombinant TLK1, Active protein, GST Tag (V2LY-0526-LY7262)

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Target: TLK1

Expressed Host: Baculovirus-Insect Cells

Sequence: Amino Acid: Full Length

Tag: GST Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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