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Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3316) (CBMAB-T2604-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLN1 (Talin 1). The antibody can be used for immunoassay techniques, such as WB.
See all TLN1 antibodies

Summary

Host Animal
Mouse
Specificity
Chicken, Frog, Human, Mouse, Rat
Clone
CBYJT-3316
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified chicken gizzard talin
Specificity
Chicken, Frog, Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1.2% Sodium Acetate, 2 mg BSA
Preservative
0.01 mg Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TLN1 Gene(Protein Coding) Talin 1
Introduction
TLN1 is probably involved in connections of major cytoskeletal structures to the plasma membrane. Talin is a high molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
Entrez Gene ID
Human7094
Mouse21894
Rat313494
Chicken395194
Frog733752
UniProt ID
HumanQ9Y490
MouseP26039
RatG3V852
ChickenP54939
FrogF7D9P4
Alternative Names
talin-1
Function
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Cortical actin cytoskeleton organizationIEA:Ensembl
Integrin activationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Regulation of focal adhesion assembly1 PublicationIC:ComplexPortal
Cellular Location
Cell projection, ruffle membrane
Cytoplasm, cytoskeleton
Cell surface
Cell junction, focal adhesion
Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).
PTM
Phosphorylated. PAX5 binding increases phosphorylation (By similarity).
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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