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TLN1

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Full Name
TLN1 Gene(Protein Coding) Talin 1
Function
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Cortical actin cytoskeleton organizationIEA:Ensembl
Integrin activationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Regulation of focal adhesion assembly1 PublicationIC:ComplexPortal
Cellular Location
Cell projection, ruffle membrane
Cytoplasm, cytoskeleton
Cell surface
Cell junction, focal adhesion
Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).
PTM
Phosphorylated. PAX5 binding increases phosphorylation (By similarity).
Ubiquitinated by XIAP/BIRC4.
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Anti-TLN1 antibodies

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Mouse Anti-TLN1 Recombinant Antibody (97H6) (CBMAB-T2609-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 97H6
Application*: WB, E, IH, IC, IF, IP
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (8e6) (CBMAB-0316-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: 8e6
Application*: E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (8B11) (CBMAB-A9144-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 8B11
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (5D9) (CBMAB-A9143-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5D9
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (5D1) (CBMAB-A9142-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 5D1
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (5C1) (CBMAB-A9141-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5C1
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (4G4) (CBMAB-A9140-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4G4
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (4C8) (CBMAB-A9139-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 4C8
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (1H7) (CBMAB-A9138-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 1H7
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (1A5) (CBMAB-A9137-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 1A5
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (1A11) (CBMAB-A9136-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 1A11
Application*: WB, E
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (2E10) (CBMAB-A9135-LY)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 2E10
Application*: WB, E
Datasheet SDS

Recombinant Mouse Anti-TLN1 Recombinant Antibody (93E12) (CBMAB-XB1145-YC)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 93E12
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-Tln1 Recombinant Antibody (CBYJT-3325) (CBMAB-T2616-YJ)

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Target: Tln1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3325
Application*: WB, E, IC, IF, IP
Datasheet SDS

Rabbit Anti-TLN1 Recombinant Antibody (CBYJT-3324) (CBMAB-T2615-YJ)

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Target: TLN1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: CBYJT-3324
Application*: WB, P
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3323) (CBMAB-T2614-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-3323
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3322) (CBMAB-T2613-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: CBYJT-3322
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (TA205) (CBMAB-T2612-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Rabbit
Clone: TA205
Application*: WB, F, IH, IC, IF, IP, C
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3321) (CBMAB-T2611-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Rabbit
Clone: CBYJT-3321
Application*: F, IH, IP
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3320) (CBMAB-T2610-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Chicken, Rabbit
Clone: CBYJT-3320
Application*: IC, IH, IP, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3319) (CBMAB-T2608-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBYJT-3319
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3318) (CBMAB-T2607-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3318
Application*: IF, IP, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3317) (CBMAB-T2606-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3317
Application*: IH, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (Tal-33) (CBMAB-T2605-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Frog, Human, Mouse, Rat
Clone: Tal-33
Application*: E, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3316) (CBMAB-T2604-YJ)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken, Frog, Human, Mouse, Rat
Clone: CBYJT-3316
Application*: WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (9i120) (CBMAB-R4024-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9i120
Application*: F, IH, IP
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (2-00E-010) (CBMAB-R4023-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat
Clone: 2-00E-010
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (10K362) (CBMAB-R4022-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Chicken
Clone: 10K362
Application*: WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (10H17) (CBMAB-R4021-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10H17
Application*: IH, WB
Datasheet SDS

Mouse Anti-TLN1 Recombinant Antibody (10g65) (CBMAB-R4020-CN)

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Target: TLN1
Host: Mouse
Antibody Isotype: IgG
Specificity: Chicken
Clone: 10g65
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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