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TLN1

This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]

Full Name

TLN1 Gene(Protein Coding) Talin 1

Function

Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).

Biological Process

Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Cortical actin cytoskeleton organizationIEA:Ensembl
Integrin activationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Regulation of focal adhesion assembly1 PublicationIC:ComplexPortal

Cellular Location

Cell projection, ruffle membrane
Cytoplasm, cytoskeleton
Cell surface
Cell junction, focal adhesion
Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).

PTM

Phosphorylated. PAX5 binding increases phosphorylation (By similarity).
Ubiquitinated by XIAP/BIRC4.

Anti-TLN1 antibodies

Recombinant Mouse Anti-TLN1 Recombinant Antibody (93E12) (CBMAB-XB1145-YC)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 93E12

Application*: E, IF, IP, WB

Mouse Anti-TLN1 Recombinant Antibody (9i120) (CBMAB-R4024-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9i120

Application*: F, IH, IP

Mouse Anti-TLN1 Recombinant Antibody (2-00E-010) (CBMAB-R4023-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: 2-00E-010

Application*: E, IH, WB

Mouse Anti-TLN1 Recombinant Antibody (10K362) (CBMAB-R4022-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Chicken

Clone: 10K362

Application*: WB

Rabbit Anti-TLN1 Recombinant Antibody (CBYJT-3324) (CBMAB-T2615-YJ)

SDS

Target: TLN1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Hamster, Monkey

Clone: CBYJT-3324

Application*: WB, P

Mouse Anti-TLN1 Recombinant Antibody (10H17) (CBMAB-R4021-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 10H17

Application*: IH, WB

Mouse Anti-TLN1 Recombinant Antibody (10g65) (CBMAB-R4020-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG

Specificity: Chicken

Clone: 10g65

Application*: WB

Mouse Anti-TLN1 Recombinant Antibody (8e6) (CBMAB-0316-CN)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Chicken

Clone: 8e6

Application*: E

Mouse Anti-TLN1 Recombinant Antibody (2E10) (CBMAB-A9135-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 2E10

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (1A11) (CBMAB-A9136-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 1A11

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (1A5) (CBMAB-A9137-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: 1A5

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (1H7) (CBMAB-A9138-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: 1H7

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (4C8) (CBMAB-A9139-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: 4C8

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (4G4) (CBMAB-A9140-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4G4

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (5C1) (CBMAB-A9141-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5C1

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (5D1) (CBMAB-A9142-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 5D1

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (5D9) (CBMAB-A9143-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5D9

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (8B11) (CBMAB-A9144-LY)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 8B11

Application*: WB, E

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3316) (CBMAB-T2604-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Chicken, Frog, Human, Mouse, Rat

Clone: CBYJT-3316

Application*: WB

Mouse Anti-TLN1 Recombinant Antibody (Tal-33) (CBMAB-T2605-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Chicken, Frog, Human, Mouse, Rat

Clone: Tal-33

Application*: E, WB

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3317) (CBMAB-T2606-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3317

Application*: IH, WB

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3318) (CBMAB-T2607-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-3318

Application*: IF, IP, WB

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3319) (CBMAB-T2608-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human

Clone: CBYJT-3319

Application*: E, IH, WB

Mouse Anti-TLN1 Recombinant Antibody (97H6) (CBMAB-T2609-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 97H6

Application*: WB, E, IH, IC, IF, IP

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3320) (CBMAB-T2610-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Chicken, Rabbit

Clone: CBYJT-3320

Application*: IC, IH, IP, WB

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3321) (CBMAB-T2611-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Chicken, Rabbit

Clone: CBYJT-3321

Application*: F, IH, IP

Mouse Anti-TLN1 Recombinant Antibody (TA205) (CBMAB-T2612-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Chicken, Rabbit

Clone: TA205

Application*: WB, F, IH, IC, IF, IP, C

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3322) (CBMAB-T2613-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: CBYJT-3322

Application*: E, WB, IH

Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3323) (CBMAB-T2614-YJ)

SDS

Target: TLN1

Host: Mouse

Antibody Isotype: IgG3, κ

Specificity: Human, Mouse, Rat

Clone: CBYJT-3323

Application*: E, WB, IH

Mouse Anti-Tln1 Recombinant Antibody (CBYJT-3325) (CBMAB-T2616-YJ)

SDS

Target: Tln1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYJT-3325

Application*: WB, E, IC, IF, IP

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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