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Mouse Anti-TLN1 Recombinant Antibody (CBYJT-3323) (CBMAB-T2614-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TLN1 (Talin 1). The antibody can be used for immunoassay techniques, such as ELISA, WB, IHC.
See all TLN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYJT-3323
Antibody Isotype
IgG3, κ
Application
ELISA, WB, IHC

Basic Information

Immunogen
TLN1 (NP_006280, 1052 a.a. ~ 1150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1052-1150

Target

Full Name
TLN1 Gene(Protein Coding) Talin 1
Introduction
TLN1 is a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. TLN1 plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
Entrez Gene ID
Human7094
Mouse21894
Rat313494
UniProt ID
HumanQ9Y490
MouseP26039
RatG3V852
Alternative Names
Talin 1; TLN; KIAA1027; Talin-1; ILWEQ
Function
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Cortical actin cytoskeleton organizationIEA:Ensembl
Integrin activationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Regulation of focal adhesion assembly1 PublicationIC:ComplexPortal
Cellular Location
Cell projection, ruffle membrane
Cytoplasm, cytoskeleton
Cell surface
Cell junction, focal adhesion
Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).
PTM
Phosphorylated. PAX5 binding increases phosphorylation (By similarity).
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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