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Mouse Anti-TLN1 Recombinant Antibody (9i120) (CBMAB-R4024-CN)

This product is a Mouse antibody that recognizes TLN1. The antibody 9i120 can be used for immunoassay techniques such as: FC, IHC, IP.
See all TLN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9i120
Antibody Isotype
IgG1
Application
FC, IHC, IP

Basic Information

Immunogen
Human platelet talin
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid

Target

Full Name
TLN1 Gene(Protein Coding) Talin 1
Introduction
The gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009]
Entrez Gene ID
7094
UniProt ID
Q9Y490
Alternative Names
TLN; ILWEQ; talin-1
Function
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity).
Biological Process
Cell-cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell junction assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cell-substrate junction assemblyIEA:Ensembl
Cortical actin cytoskeleton organizationIEA:Ensembl
Integrin activationIEA:Ensembl
Integrin-mediated signaling pathwayIEA:Ensembl
Platelet aggregationManual Assertion Based On ExperimentHMP:UniProtKB
Regulation of focal adhesion assembly1 PublicationIC:ComplexPortal
Cellular Location
Cell projection, ruffle membrane
Cytoplasm, cytoskeleton
Cell surface
Cell junction, focal adhesion
Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than fibrillar adhesions (By similarity).
PTM
Phosphorylated. PAX5 binding increases phosphorylation (By similarity).
Ubiquitinated by XIAP/BIRC4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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