Sign in or Register   Sign in or Register
  |  

Rat Anti-Tlr7 Recombinant Antibody (CBYJT-3417) (CBMAB-T2734-YJ)

Provided herein is a Rat monoclonal antibody, which binds to Tlr7 (Toll-Like Receptor 7). The antibody can be used for immunoassay techniques, such as WB.
See all Tlr7 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-3417
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse TLR7
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TLR7 Gene(Protein Coding) Toll Like Receptor 7
Introduction
TLR7 is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. TLR7 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Entrez Gene ID
170743
UniProt ID
P58681
Alternative Names
toll-like receptor 7; Toll like receptor 7
Function
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612).
Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371).
Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543).
In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371).
Biological Process
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process cellular response to virusSource:Ensembl
Biological Process defense response to virusSource:UniProtKB1 Publication
Biological Process I-kappaB kinase/NF-kappaB signalingSource:GO_Central1 Publication
Biological Process I-kappaB phosphorylationSource:BHF-UCL1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process JNK cascadeSource:Ensembl
Biological Process positive regulation of chemokine productionSource:BHF-UCL1 Publication
Biological Process positive regulation of inflammatory responseSource:BHF-UCL1 Publication
Biological Process positive regulation of interferon-alpha productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-beta productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-gamma productionSource:UniProtKB1 Publication
Biological Process positive regulation of interleukin-6 productionSource:GO_Central1 Publication
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage cytokine productionSource:Ensembl
Biological Process positive regulation of NIK/NF-kappaB signalingSource:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process regulation of protein phosphorylationSource:Ensembl
Biological Process toll-like receptor 7 signaling pathwaySource:GO_Central1 Publication
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum membrane
Endosome
Lysosome
Cytoplasmic vesicle, phagosome
Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Involvement in disease
Immunodeficiency 74, COVID19-related, X-linked (IMD74):
An X-linked recessive immunologic disorder characterized by impaired type I and type II interferon responses due to defective TLR7 signaling. Individuals with TLR7 deficiency develop severe respiratory insufficiency in response to infection with SARS-CoV-2 coronavirus. Death from respiratory failure may occur.
Topology
Extracellular: 27-839
Helical: 840-860
Cytoplasmic: 861-1049
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rat Anti-Tlr7 Recombinant Antibody (CBYJT-3417)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare