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Mouse Anti-TMA16 Recombinant Antibody (4A6) (CBMAB-A0982-LY)

The product is antibody recognizes C4orf43. The antibody 4A6 immunoassay techniques such as: WB, ELISA.
See all TMA16 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
C4orf43 (AAH11842.1, 1 a.a. ~ 203 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TMA16 Gene(Protein Coding)


Translation Machinery Associated 16 Homolog
Entrez Gene ID
55319
UniProt ID
Q96EY4
Alternative Names
FLJ11184
Function
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474).
Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576).
Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).
Biological Process
Biological Process cell adhesionSource:UniProtKB1 Publication
Biological Process phagocytosisSource:UniProtKB1 Publication
Biological Process positive regulation of protein exit from endoplasmic reticulumSource:UniProtKB1 Publication
Biological Process positive regulation of protein localization to cell surfaceSource:UniProtKB1 Publication
Biological Process protein localization to membraneSource:GO_Central1 Publication
Biological Process regulation of intracellular pHSource:UniProtKB1 Publication
Biological Process response to hypoxiaSource:UniProtKB1 Publication
Biological Process vacuolar proton-transporting V-type ATPase complex assemblySource:UniProtKB1 Publication
Cellular Location
Membrane
Golgi apparatus
Early endosome
Topology
Extracellular: 24-281
Helical: 282-302
Cytoplasmic: 303-346
Helical: 347-367
Extracellular: 368-376
Helical: 377-397
Cytoplasmic: 398-416
Helical: 417-437
Extracellular: 438-449
Helical: 450-470
Cytoplasmic: 471-501
Helical: 502-522
Extracellular: 523-535
Helical: 536-556
Cytoplasmic: 557-570
Helical: 571-591
Extracellular: 592-598
Helical: 599-619
Cytoplasmic: 620-642
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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