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Mouse Anti-TMA16 Recombinant Antibody (4A6) (CBMAB-C6607-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4A6
Antibody Isotype
IgG1, κ
Application
ELISA, IHC-F, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-204 from human C4orf43 (AAH11842) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TMA16 Gene(Protein Coding)


Translation Machinery Associated 16 Homolog
Introduction
TMA16 (Translation Machinery Associated 16 Homolog) is a Protein Coding gene.
Entrez Gene ID
55319
UniProt ID
Q96EY4
Alternative Names
Translation Machinery Associated 16 Homolog; C4orf43; Translation Machinery Associated 16 Homolog (S. Cerevisiae); Translation Machinery-Associated Protein 16; Chromosome 4 Open Reading Frame 43; UPF0534 Protein C4orf43;
Function
Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474).
Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576).
Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578).
Biological Process
Biological Process cell adhesionSource:UniProtKB1 Publication
Biological Process phagocytosisSource:UniProtKB1 Publication
Biological Process positive regulation of protein exit from endoplasmic reticulumSource:UniProtKB1 Publication
Biological Process positive regulation of protein localization to cell surfaceSource:UniProtKB1 Publication
Biological Process protein localization to membraneSource:GO_Central1 Publication
Biological Process regulation of intracellular pHSource:UniProtKB1 Publication
Biological Process response to hypoxiaSource:UniProtKB1 Publication
Biological Process vacuolar proton-transporting V-type ATPase complex assemblySource:UniProtKB1 Publication
Cellular Location
Membrane
Golgi apparatus
Early endosome
Topology
Extracellular: 24-281
Helical: 282-302
Cytoplasmic: 303-346
Helical: 347-367
Extracellular: 368-376
Helical: 377-397
Cytoplasmic: 398-416
Helical: 417-437
Extracellular: 438-449
Helical: 450-470
Cytoplasmic: 471-501
Helical: 502-522
Extracellular: 523-535
Helical: 536-556
Cytoplasmic: 557-570
Helical: 571-591
Extracellular: 592-598
Helical: 599-619
Cytoplasmic: 620-642
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For research use only. Not intended for any clinical use.

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