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Mouse Anti-TMEM100 Recombinant Antibody (CBYJT-3480) (CBMAB-T2805-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMEM100 (Transmembrane Protein 100). The antibody can be used for immunoassay techniques, such as WB, IHC, ICC, IF, IHC-P.
See all TMEM100 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3480
Antibody Isotype
IgG1
Application
WB, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Protein expressed in 293T cell transfected with human TMEM100 expression vector
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane Protein 100
Introduction
TMEM100 (Transmembrane Protein 100) plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. It is involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
Entrez Gene ID
55273
UniProt ID
Q9NV29
Alternative Names
Transmembrane Protein 100
Function
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.
Biological Process
Biological Process angiogenesisSource:Ensembl
Biological Process arterial endothelial cell differentiationSource:Ensembl
Biological Process BMP signaling pathwaySource:UniProtKB1 Publication
Biological Process cellular response to BMP stimulusSource:UniProtKB1 Publication
Biological Process epithelial to mesenchymal transition involved in endocardial cushion formationSource:Ensembl
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process positive regulation of endothelial cell differentiationSource:UniProtKB
Biological Process positive regulation of vasculogenesisSource:UniProtKB
Biological Process protein kinase B signalingSource:Ensembl
Biological Process regulation of calcium-mediated signalingSource:Ensembl
Biological Process regulation of sensory perception of painSource:UniProtKB
Biological Process vasculogenesisSource:Ensembl
Cellular Location
Cell membrane
Membrane
Perikaryon
Cytoplasm, perinuclear region
Endoplasmic reticulum
Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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