TMEM100

TMEM100 (Transmembrane Protein 100) plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. It is involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.

Full Name

Transmembrane Protein 100

Function

Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.

Biological Process

Biological Process angiogenesisSource:Ensembl
Biological Process arterial endothelial cell differentiationSource:Ensembl
Biological Process BMP signaling pathwaySource:UniProtKB1 Publication
Biological Process cellular response to BMP stimulusSource:UniProtKB1 Publication
Biological Process epithelial to mesenchymal transition involved in endocardial cushion formationSource:Ensembl
Biological Process in utero embryonic developmentSource:Ensembl
Biological Process Notch signaling pathwaySource:Ensembl
Biological Process positive regulation of endothelial cell differentiationSource:UniProtKB
Biological Process positive regulation of vasculogenesisSource:UniProtKB
Biological Process protein kinase B signalingSource:Ensembl
Biological Process regulation of calcium-mediated signalingSource:Ensembl
Biological Process regulation of sensory perception of painSource:UniProtKB
Biological Process vasculogenesisSource:Ensembl

Cellular Location

Cell membrane
Membrane
Perikaryon
Cytoplasm, perinuclear region
Endoplasmic reticulum
Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.