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Mouse Anti-TMIGD2 Recombinant Antibody (CBYJT-3535) (CBMAB-T2860-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2). The antibody can be used for immunoassay techniques, such as FC, IHC, CyTOF.
See all TMIGD2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3535
Antibody Isotype
IgG2b
Application
FC, IHC, CyTOF

Basic Information

Immunogen
Partial recombinant human CD28H protein (amino acids 23-150) [UniProt Q96BF3]
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 23-150

Target

Full Name
Transmembrane And Immunoglobulin Domain Containing 2
Introduction
TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to TMIGD2 include coreceptor activity.
Entrez Gene ID
126259
UniProt ID
Q96BF3
Alternative Names
Transmembrane And Immunoglobulin Domain Containing 2; Immunoglobulin And Proline-Rich Receptor 1; CD28 Homologue; CD28 Homolog; IGPR-1; CD28H; IGPR1
Function
Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Biological Process
Biological Process immune responseSource:GO_Central1 Publication
Biological Process positive regulation of activated T cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of angiogenesisSource:CACAO1 Publication
Biological Process positive regulation of cytokine productionSource:UniProtKB1 Publication
Biological Process T cell costimulationSource:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 23-150
Helical: 151-171
Cytoplasmic: 172-282
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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