TMIGD2

TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to TMIGD2 include coreceptor activity.

Transmembrane And Immunoglobulin Domain Containing 2

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Biological Process immune responseSource:GO_Central1 Publication
Biological Process positive regulation of activated T cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of angiogenesisSource:CACAO1 Publication
Biological Process positive regulation of cytokine productionSource:UniProtKB1 Publication
Biological Process T cell costimulationSource:UniProtKB1 Publication

Cell membrane

Extracellular: 23-150
Helical: 151-171
Cytoplasmic: 172-282

N-glycosylated.