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TMIGD2

TMIGD2 (Transmembrane And Immunoglobulin Domain Containing 2) is a Protein Coding gene. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions. Gene Ontology (GO) annotations related to TMIGD2 include coreceptor activity.

Full Name

Transmembrane And Immunoglobulin Domain Containing 2

Function

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Biological Process

Biological Process immune responseSource:GO_Central1 Publication
Biological Process positive regulation of activated T cell proliferationSource:UniProtKB1 Publication
Biological Process positive regulation of angiogenesisSource:CACAO1 Publication
Biological Process positive regulation of cytokine productionSource:UniProtKB1 Publication
Biological Process T cell costimulationSource:UniProtKB1 Publication

Cellular Location

Cell membrane

Topology

Extracellular: 23-150
Helical: 151-171
Cytoplasmic: 172-282

PTM

N-glycosylated.

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Anti-TMIGD2 antibodies

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Mouse Anti-TMIGD2 Recombinant Antibody (CBYJT-3537) (CBMAB-T2862-YJ)

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Target: TMIGD2

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-3537

Application*: WB, IP, IF, E

Mouse Anti-TMIGD2 Recombinant Antibody (CBYJT-3536) (CBMAB-T2861-YJ)

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Target: TMIGD2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-3536

Application*: F, MC

Mouse Anti-TMIGD2 Recombinant Antibody (CBYJT-3535) (CBMAB-T2860-YJ)

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Target: TMIGD2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-3535

Application*: F, IH, MC

Mouse Anti-TMIGD2 Recombinant Antibody (CBYJT-3534) (CBMAB-T2859-YJ)

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Target: TMIGD2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJT-3534

Application*: F, IH, MC

Human Recombinant TMIGD2 protein, His Tag (V2LY-0526-LY2768)

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Target: TMIGD2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-150

Tag: His Tag

Human Recombinant TMIGD2 protein, ECD, Biotin Conjugated, His & AVI Tag (V2LY-0526-LY2767)

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Target: TMIGD2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-150

Tag: His & AVI Tag

Human Recombinant TMIGD2 protein, ECD, hFc Tag (V2LY-0526-LY2766)

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Target: TMIGD2

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-150

Tag: hFc Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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