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Mouse Anti-TMSB4X Recombinant Antibody (4H7) (CBMAB-A9228-LY)

The product is antibody recognizes TMSB4X. The antibody 4H7 immunoassay techniques such as: WB, ELISA.
See all TMSB4X antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4H7
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
TMSB4X (NP_066932, 1 a.a. ~ 44 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
thymosin beta 4, X-linked
Introduction
This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq]
Entrez Gene ID
7114
UniProt ID
P62328
Alternative Names
FX; PTMB4; TB4X; TMSB4
Function
Plays an important role in the organization of the cytoskeleton (PubMed:1999398, PubMed:10848969).
Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:1999398, PubMed:10848969).
Hemoregulatory peptide AcSDKP
Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679).
Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).
Biological Process
Biological Process actin filament organizationSource:InterPro
Biological Process cytoplasmic sequestering of NF-kappaBSource:CAFA1 Publication
Biological Process negative regulation of cell cycle G1/S phase transitionSource:UniProtKB
Biological Process negative regulation of hematopoietic stem cell differentiationSource:UniProtKB
Biological Process negative regulation of interleukin-8 productionSource:CAFA1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activitySource:CAFA1 Publication
Biological Process negative regulation of NIK/NF-kappaB signalingSource:CAFA1 Publication
Biological Process negative regulation of RNA polymerase II regulatory region sequence-specific DNA bindingSource:CAFA1 Publication
Biological Process positive regulation of ATP biosynthetic processSource:CAFA1 Publication
Biological Process positive regulation of blood vessel endothelial cell migrationSource:CAFA1 Publication
Biological Process positive regulation of endothelial cell chemotaxisSource:CAFA1 Publication
Biological Process positive regulation of proton-transporting ATP synthase activity, rotational mechanismSource:CAFA1 Publication
Biological Process regulation of cell migrationSource:GO_Central1 Publication
Biological Process regulation of inflammatory responseSource:CAFA1 Publication
Biological Process regulation of NIK/NF-kappaB signalingSource:CAFA1 Publication
Biological Process sequestering of actin monomersSource:CAFA2 Publications
Biological Process tumor necrosis factor-mediated signaling pathwaySource:CAFA1 Publication
Cellular Location
Cytoplasm, cytoskeleton
PTM
Hemoregulatory peptide AcSDKP
AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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