TMSB4X

This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq]

Full Name

thymosin beta 4, X-linked

Function

Plays an important role in the organization of the cytoskeleton (PubMed:1999398, PubMed:10848969).
Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:1999398, PubMed:10848969).
Hemoregulatory peptide AcSDKP
Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679).
Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity).

Biological Process

Biological Process actin filament organizationSource:InterPro
Biological Process cytoplasmic sequestering of NF-kappaBSource:CAFA1 Publication
Biological Process negative regulation of cell cycle G1/S phase transitionSource:UniProtKB
Biological Process negative regulation of hematopoietic stem cell differentiationSource:UniProtKB
Biological Process negative regulation of interleukin-8 productionSource:CAFA1 Publication
Biological Process negative regulation of NF-kappaB transcription factor activitySource:CAFA1 Publication
Biological Process negative regulation of NIK/NF-kappaB signalingSource:CAFA1 Publication
Biological Process negative regulation of RNA polymerase II regulatory region sequence-specific DNA bindingSource:CAFA1 Publication
Biological Process positive regulation of ATP biosynthetic processSource:CAFA1 Publication
Biological Process positive regulation of blood vessel endothelial cell migrationSource:CAFA1 Publication
Biological Process positive regulation of endothelial cell chemotaxisSource:CAFA1 Publication
Biological Process positive regulation of proton-transporting ATP synthase activity, rotational mechanismSource:CAFA1 Publication
Biological Process regulation of cell migrationSource:GO_Central1 Publication
Biological Process regulation of inflammatory responseSource:CAFA1 Publication
Biological Process regulation of NIK/NF-kappaB signalingSource:CAFA1 Publication
Biological Process sequestering of actin monomersSource:CAFA2 Publications
Biological Process tumor necrosis factor-mediated signaling pathwaySource:CAFA1 Publication

Cellular Location

Cytoplasm, cytoskeleton

PTM

Hemoregulatory peptide AcSDKP
AcSDKP is inactivated by ACE, which removes the dipeptide Lys-Pro from its C-terminus.