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Mouse Anti-TMX1 Recombinant Antibody (CBYJT-3589) (CBMAB-T2917-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3589
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Full length human recombinant protein of human TMX1(NP_110382) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Thioredoxin Related Transmembrane Protein 1
Introduction
TMX1 is a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. TMX1 has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides.
Entrez Gene ID
81542
UniProt ID
Q9H3N1
Alternative Names
Thioredoxin Related Transmembrane Protein 1; Protein Disulfide Isomerase Family A, Member 11; Thioredoxin-Related Transmembrane Protein 1; Thioredoxin Domain-Containing Protein 1; Transmembrane Trx-Related Protein; Thioredoxin Domain Containing 1; TXNDC1
Function
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.
Biological Process
Response to endoplasmic reticulum stress
Topology
Extracellular: 27-180
Helical: 181-203
Cytoplasmic: 204-280
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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