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Mouse Anti-TNFRSF17 Recombinant Antibody (1A4) (CBMAB-A9295-LY)

The product is antibody recognizes TNFRSF17. The antibody 1A4 immunoassay techniques such as: WB, ELISA.
See all TNFRSF17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A4
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
TNFRSF17 (AAH58291, 1 a.a. ~ 184 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFRSF17 Gene(Protein Coding) TNF Receptor Superfamily Member 17
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]
Entrez Gene ID
608
UniProt ID
Q02223
Alternative Names
BCM; BCMA; CD269
Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process lymphocyte homeostasis Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Cell membrane
Endomembrane system
Involvement in disease
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Topology
Extracellular: 1-54
Helical: 55-77
Cytoplasmic: 78-184
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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