TNFRSF17
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF17 Gene(Protein Coding) TNF Receptor Superfamily Member 17
Function
Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process lymphocyte homeostasis Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Biological Process lymphocyte homeostasis Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Cell membrane
Endomembrane system
Endomembrane system
Involvement in disease
A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Topology
Extracellular: 1-54
Helical: 55-77
Cytoplasmic: 78-184
Helical: 55-77
Cytoplasmic: 78-184
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Anti-TNFRSF17 antibodies
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CompareTarget: TNFRSF17
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3750
Application*: F, IC
Target: TNFRSF17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E6D7B
Application*: WB, IP, P, F
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 8H2
Application*: WB, E
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8B4
Application*: WB, E
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D1
Application*: WB, E
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A4
Application*: WB, E
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: BCMA/2366
Application*: PA, P
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 8E11
Application*: WB, E
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D163
Application*: F, IP, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H6
Application*: E, WB
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: 3D44
Application*: WB, N
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F10
Application*: E, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D12G9
Application*: WB, E, F
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: Vicky-2
Application*: IP, F, WB, FN, B
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: Vicky-1
Application*: WB, E, F, IC, IF, IH, B
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-6002
Application*: WB, IP, IF, E
Target: TNFRSF17
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-6001
Application*: WB, IP, P, F
Target: TNFRSF17
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0803
Application*: F
Target: Tnfrsf17
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3758
Application*: WB, N
Target: Tnfrsf17
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3757
Application*: N, WB
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3756
Application*: IC, F
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3755
Application*: E, F
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3754
Application*: E, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3753
Application*: E, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3752
Application*: WB, B
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3751
Application*: E, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3749
Application*: E, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3748
Application*: E, WB
Target: TNFRSF17
Host: Rat
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3747
Application*: N, WB
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-3171
Application*: F
Target: TNFRSF17
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4648
Application*: F
Target: TNFRSF17
Specificity: Human
Target: TNFRSF17
Specificity: Human
Target: TNFRSF17
Specificity: Human
Target: TNFRSF17
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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