Mouse Anti-TNFRSF17 Recombinant Antibody (CBYJT-3755) (CBMAB-T3138-YJ)

Name: Mouse Anti-TNFRSF17 Recombinant Antibody (CBYJT-3755)
SKU: CBMAB-T3138-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBYJT-3755

Application

ELISA, FC

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

50 mM PBS, 100 mM KCl, 150 mM NaCl, 0.5 mg/mL Gentamicin Sulfate, pH 7.5

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

TNFRSF17 Gene(Protein Coding) TNF Receptor Superfamily Member 17

Introduction

TNFRSF17 is a member of the TNF-receptor superfamily. It is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. It has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. It also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.

Entrez Gene ID

608

UniProt ID

Q02223

Alternative Names

TNF Receptor Superfamily Member 17; B-Cell Maturation Protein; BCMA; BCM; Tumor Necrosis Factor Receptor Superfamily, Member 17; Tumor Necrosis Factor Receptor Superfamily Member 17

Function

Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process lymphocyte homeostasis Source:Ensembl
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro

Cellular Location

Cell membrane
Endomembrane system

Involvement in disease

A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Topology

Extracellular: 1-54
Helical: 55-77
Cytoplasmic: 78-184

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

TNFRSF17 Matched Antibody Pair (1224) (CAT#: APMAB-1224LY)

TNFRSF17 Matched Antibody Pair (1225) (CAT#: APMAB-1225LY)

TNFRSF17 Matched Antibody Pair (1226) (CAT#: APMAB-1226LY)

TNFRSF17 Matched Antibody Pair (1227) (CAT#: APMAB-1227LY)

Related Products

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Mouse Anti-TNFRSF17 Recombinant Antibody (BCMA/2366) (CAT#: CBMAB-T6012-YJ)

Mouse Anti-TNFRSF17 Recombinant Antibody (CBYJT-3752) (CAT#: CBMAB-T3135-YJ)

Rat Anti-Tnfrsf17 Recombinant Antibody (6D163) (CAT#: CBMAB-T6010-YJ)

TNFRSF17 Matched Antibody Pair (1225) (CAT#: APMAB-1225LY)

Mouse Anti-TNFRSF17 Recombinant Antibody (3H6) (CAT#: CBMAB-T6009-YJ)

Mouse Anti-TNFRSF17 Recombinant Antibody (CBYJT-3753) (CAT#: CBMAB-T3136-YJ)

Mouse Anti-TNFRSF17 Recombinant Antibody (1A4) (CAT#: CBMAB-A9295-LY)

Rat Anti-TNFRSF17 Recombinant Antibody (CBYJT-3756) (CAT#: CBMAB-T3139-YJ)

Rat Anti-TNFRSF17 Recombinant Antibody (CBYJT-3750) (CAT#: CBMAB-T3133-YJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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