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Mouse Anti-TNFRSF25 Recombinant Antibody (1R12) (CBMAB-D2326-YC)

Provided herein is a Mouse monoclonal antibody, which binds to TNF Receptor Superfamily Member 25 (TNFRSF25). The antibody can be used for immunoassay techniques, such as WB.
See all TNFRSF25 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1R12
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Human recombinant TNFRSF25 EC domain
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF25 Gene(Protein Coding) TNF Receptor Superfamily Member 25
Introduction
TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus.
Entrez Gene ID
8718
UniProt ID
Q93038
Alternative Names
TNF Receptor Superfamily Member 25; Tumor Necrosis Factor Receptor Superfamily, Member 12 (Translocating Chain-Association Membrane Protein); Lymphocyte-Associated Receptor Of Death; Apoptosis-Mediating Receptor TRAMP; Apoptosis-Mediating Receptor DR3; Apoptosis-Inducing Receptor AIR; Protein WSL-1; TNFRSF12; APO-3; DDR3; LARD; DR3; Tumor Necrosis Factor Receptor Superfamily, Member 25; Tumor Necrosis Factor Receptor Superfamily Member 25;
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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