TNFRSF25
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
Full Name
TNFRSF25 Gene(Protein Coding) TNF Receptor Superfamily Member 25
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251
Helical: 36-56
Extracellular: 57-251
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Anti-TNFRSF25 antibodies
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CompareTarget: TNFRSF25
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D5Q2R
Application*: WB, IP
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3845
Application*: WB
Target: TNFRSF25
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: mDcR1-3
Application*: F
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: JD3
Application*: F
Target: TNFRSF25
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D4O3X
Application*: WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3A16
Application*: WB, E
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H2
Application*: WB, E
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D22
Application*: WB, E
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4E3
Application*: E, E
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3848
Application*: SE, E, WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3847
Application*: E
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3846
Application*: E, WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3844
Application*: E, WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3843
Application*: WB
Target: TNFRSF25
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 7H65
Application*: E, IH, WB
Target: TNFRSF25
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYCD-559
Application*: WB
Target: TNFRSF25
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYCD-558
Application*: WB, IC
Target: TNFRSF25
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 4C12
Application*: AG, F
Target: TNFRSF25
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 11H6L9
Application*: F, IC, IF, WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYCD-520
Application*: F, WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1R12
Application*: WB
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3855
Application*: IH, F
Target: TNFRSF25
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2026
Application*: F
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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