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Rat Anti-TNFRSF4 Recombinant Antibody (OX-86) (CBMAB-1075-LY)

This product is rat antibody recognizes mouse OX40 (CD134). The antibody OX-86 immunoassay techniques such as: Activation.
See all TNFRSF4 antibodies
Published Data
Fig.1 Ox40 expression on splenic and kidney-infiltrating CD4 T cell subsets in NZB/W F1 mice.
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Fig.2 Ox40− and Ox40+ cells (gated on live CD19−CD3+CD4+ T cells) intracellularly stained for Foxp3 and overlaid.
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Fig.3 Anti-Ox40 agonist mAb treatment exacerbates renal disease and IgM deposition in NZB/W F1 mice.
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Fig.4 Effect of agonistic anti-OX40 and/or blocking anti-PD-L1 antibody upon helped or unhelped donor.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
OX-86
Antibody Isotype
IgG1
Application
Activation

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tumor necrosis factor receptor superfamily member 4
Introduction
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Entrez Gene ID
22163
UniProt ID
P47741
Alternative Names
Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Biological Process
Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Topology
Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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