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TNFRSF4

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008]
Full Name
Tumor necrosis factor receptor superfamily member 4
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Biological Process
Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Topology
Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277

Anti-TNFRSF4 antibodies

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Rat Anti-Tnfrsf4 Recombinant Antibody (CBYJT-3856) (CBMAB-T3251-YJ)

Datasheet SDS
Target: Tnfrsf4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3856
Application*: F, C

Rat Anti-TNFRSF4 Recombinant Antibody (CBYJT-3855) (CBMAB-T3250-YJ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3855
Application*: F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBYJT-3854) (CBMAB-T3249-YJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3854
Application*: E, F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBYJT-3853) (CBMAB-T3248-YJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3853
Application*: E, F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBYJT-3852) (CBMAB-T3247-YJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: CBYJT-3852
Application*: F, WB

Rabbit Anti-TNFRSF4 Recombinant Antibody (RM313) (CBMAB-BR470LY)

Datasheet SDS
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM313
Application*: IHC, WB

Rabbit Anti-TNFRSF4 Recombinant Antibody (CBR042F) (CBMAB-BT089LY)

Datasheet SDS
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR042F
Application*: WB, IP, IHC, ICC, IHC-IF

Rabbit Anti-TNFRSF4 Recombinant Antibody (D1S6L) (CBMAB-CP2809-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1S6L
Application*: WB, IP, IF (IC), F

Rabbit Anti-TNFRSF4 Recombinant Antibody (D4N3K) (CBMAB-CP2808-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4N3K
Application*: WB

Rat Anti-TNFRSF4 Recombinant Antibody (MAB0833) (CBMAB-C12571-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MAB0833
Application*: F

Rat Anti-TNFRSF4 Recombinant Antibody (OX86) (CBMAB-C12570-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX86
Application*: B, F

Mouse Anti-TNFRSF4 Recombinant Antibody (10B711) (CBMAB-C0052-CN)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat, Human
Clone: 10B711
Application*: FC, WB

Mouse Anti-TNFRSF4 Recombinant Antibody (CBWJC-4531) (CBMAB-C5924WJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4531
Application*: F

Mouse Anti-TNFRSF4 Recombinant Antibody (7H163) (CBMAB-C8786-LY)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H163
Application*: E, F, IH

Rat Anti-TNFRSF4 Recombinant Antibody (CBFYC-3175) (CBMAB-C3252-FY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-3175
Application*: F, IH

Rat Anti-TNFRSF4 Recombinant Antibody (CBYY-C0154) (CBMAB-C0501-YY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBYY-C0154
Application*: F, IH, IP

Mouse Anti-TNFRSF4 Recombinant Antibody (CBYY-C0617) (CBMAB-C1905-YY)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0617
Application*: E, F, IH

Mouse Anti-TNFRSF4 Recombinant Antibody (ACT35) (CBMAB-C1709-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ACT35
Application*: F

Human Anti-TNFRSF4 Recombinant Antibody (CBXC-0901) (CBMAB-C2016-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0901
Application*: F

Human Anti-TNFRSF4 Recombinant Antibody (CBXC-0904) (CBMAB-C2019-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0904
Application*: F

Rat Anti-TNFRSF4 Recombinant Antibody (CBXC-1585) (CBMAB-C2849-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1585
Application*: F, IH

Rat Anti-TNFRSF4 Recombinant Antibody (CBXC-1586) (CBMAB-C2850-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1586
Application*: F

Mouse Anti-TNFRSF4 Recombinant Antibody (Ber-ACT35) (CBMAB-C5055-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ber-ACT35
Application*: F

Rat Anti-TNFRSF4 Recombinant Antibody (CBWJC-4527) (CBMAB-C5920WJ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-4527
Application*: C, F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBWJC-4528) (CBMAB-C5921WJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJC-4528
Application*: F

Rat Anti-TNFRSF4 Recombinant Antibody (OX-86) (CBMAB-1075-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-86
Application*: A

Mouse Anti-TNFRSF4 Recombinant Antibody (7D6) (CBMAB-O0015-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat, Human
Clone: 7D6
Application*: F, WB

Rat Anti-TNFRSF4 (AA 29-216) Recombinant Antibody (CBXO-0385) (CBMAB-O0039-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0385
Application*: WB, F, MC

Rat Anti-TNFRSF4 Recombinant Antibody (OX-86) (CBMAB-O0058-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-86
Application*: F, C

Mouse Anti-TNFRSF4 Recombinant Antibody (OX40) (CBMAB-O0083-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: OX40
Application*: F, C, IP

Rat Anti-TNFRSF4 Recombinant Antibody (CBXO-0299) (CBMAB-O0890-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0299
Application*: IF, F

Rat Anti-TNFRSF4 Recombinant Antibody (CBXO-0302) (CBMAB-O0891-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0302
Application*: IF, F

Rat Anti-TNFRSF4 Recombinant Antibody (CBXO-0307) (CBMAB-O0892-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0307
Application*: IF, F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBXO-0300) (CBMAB-O0893-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Specificity: Rat
Clone: CBXO-0300
Application*: IF, F

Mouse Anti-TNFRSF4 Recombinant Antibody (CBXO-0304) (CBMAB-O0894-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Specificity: Rat
Clone: CBXO-0304
Application*: IF, F

Rat Anti-TNFRSF4 Recombinant Antibody (W4-3) (CBMAB-O0895-CQ)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: W4-3
Application*: F

Rat Anti-TNFRSF4 Recombinant Antibody (3H1839) (CBMAB-C1209-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 3H1839
Application*: F, IH

Mouse Anti-TNFRSF4 Recombinant Antibody (3H1849) (CBMAB-C1210-LY)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 3H1849
Application*: F, IH, IP

Mouse Anti-TNFRSF4 Recombinant Antibody (BerAct35) (CBMAB-C3496WJ)

Datasheet SDS
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BerAct35
Application*: F, E, IH

Rat Anti-TNFRSF4 Recombinant Antibody (14L152) (CBMAB-C3098-LY)

Datasheet SDS
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 14L152
Application*: F, IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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