TNFRSF4
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Full Name
Tumor necrosis factor receptor superfamily member 4
Alternative Names
Tumor necrosis factor receptor superfamily member 4;ACT35 antigen;OX40L receptor;TAX transcriptionally-activated glycoprotein 1 receptor;CD134;TNFRSF4;TXGP1L;
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Biological Process
Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Topology
Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277
Helical: 215-235
Cytoplasmic: 236-277
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Anti-TNFRSF4 antibodies
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CompareTarget: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM313
Application*: IHC, WB
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: AG182
Application*: F, IH, In Vivo, WB
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4165
Application*: WB
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3973
Application*: IH, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT4291
Application*: WB
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2505
Application*: F
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR042F
Application*: WB, IP, IHC, ICC, IHC-IF
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1S6L
Application*: WB, IP, IF (IC), F
Target: TNFRSF4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4N3K
Application*: WB
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: MAB0833
Application*: F
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX86
Application*: B, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat, Human
Clone: 10B711
Application*: FC, WB
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4531
Application*: F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBWJC-4528
Application*: F
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-4527
Application*: C, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BerAct35
Application*: F, E, IH
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ber-ACT35
Application*: F
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1586
Application*: F
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-1585
Application*: F, IH
Target: TNFRSF4
Host: Human
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBXC-0904
Application*: F
Target: TNFRSF4
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0901
Application*: F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ACT35
Application*: F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0617
Application*: E, F, IH
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: CBYY-C0154
Application*: F, IH, IP
Target: Tnfrsf4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3856
Application*: F, C
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3855
Application*: F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3854
Application*: E, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3853
Application*: E, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: CBYJT-3852
Application*: F, WB
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYC-3175
Application*: F, IH
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H163
Application*: E, F, IH
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 14L152
Application*: F, IH
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: 3H1849
Application*: F, IH, IP
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 3H1839
Application*: F, IH
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: W4-3
Application*: F
Target: TNFRSF4
Host: Mouse
Specificity: Rat
Clone: CBXO-0304
Application*: IF, F
Target: TNFRSF4
Host: Mouse
Specificity: Rat
Clone: CBXO-0300
Application*: IF, F
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0307
Application*: IF, F
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0302
Application*: IF, F
Target: TNFRSF4
Host: Rat
Specificity: Mouse
Clone: CBXO-0299
Application*: IF, F
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Rat
Clone: OX40
Application*: F, C, IP
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-86
Application*: F, C
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXO-0385
Application*: WB, F, MC
Target: TNFRSF4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat, Human
Clone: 7D6
Application*: F, WB
Target: TNFRSF4
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: OX-86
Application*: A
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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