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Rat Anti-TNFRSF4 Recombinant Antibody (CBXC-1586) (CBMAB-C2850-CQ)

This product is a rat antibody that recognizes TNFRSF4. The antibody CBXC-1586 can be used for immunoassay techniques such as: FC.
See all TNFRSF4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1586
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tumor necrosis factor receptor superfamily member 4
Introduction
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
Entrez Gene ID
22163
UniProt ID
P47741
Alternative Names
TNF Receptor Superfamily Member 4; TAX Transcriptionally-Activated Glycoprotein 1 Receptor; OX40L Receptor; ACT35 Antigen; CD134 Antigen; TXGP1L; Tax-Transcriptionally Activated Glycoprotein 1 Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 4; Tumor Necrosis Factor Receptor Superfamily Member 4; Lymphoid Activation Antigene ACT35;
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Biological Process
Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Topology
Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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