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Rabbit Anti-TNFRSF4 Recombinant Antibody (CBR042F) (CBMAB-BT089LY)

The product is antibody recognizes TNFRSF4. The antibody CBR042F immunoassay techniques such as: WB, IP, IHC, ICC, IHC-IF.
See all TNFRSF4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBR042F
Antibody Isotype
IgG
Application
WB, IP, IHC, ICC, IHC-IF

Basic Information

Immunogen
aa 29-216 (ECD)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Tumor necrosis factor receptor superfamily member 4
Introduction
This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Entrez Gene ID
7293
UniProt ID
P43489
Alternative Names
TNF Superfamily Member 4; Glycoprotein Gp34; TXGP1; Tax-Transcriptionally Activated Glycoprotein 1 (34kD); Tax-Transcriptionally Activated Glycoprotein 1, 34kD; Tumor Necrosis Factor (Ligand) Superfamily, Member 4; Tumor Necrosis Factor (Ligand) Superfamily Member 4; Tumor Necrosis Factor Ligand Superfamily Member 4; TAX Transcriptionally-Activated Glycoprotein 1; Tumor Necrosis Factor Superfamily Member 4; Tumor Necrosis Factor Ligand 2B; OX40 Antigen Ligand;
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Biological Process
Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.
Topology
Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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