Rat Anti-TNFRSF4 Recombinant Antibody (CBXO-0307) (CBMAB-O0892-CQ)

Name: Rat Anti-TNFRSF4 Recombinant Antibody (CBXO-0307)
SKU: CBMAB-O0892-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

CBXO-0307

Application

IF, FC

Specificity

Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

0.2 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Tumor necrosis factor receptor superfamily member 4

Introduction

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

Entrez Gene ID

22163

UniProt ID

P47741

Alternative Names

TNF Receptor Superfamily Member 4; TAX Transcriptionally-Activated Glycoprotein 1 Receptor; OX40L Receptor; ACT35 Antigen; CD134 Antigen; TXGP1L; Tax-Transcriptionally Activated Glycoprotein 1 Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 4; Tumor Necrosis Factor Receptor Superfamily Member 4; Lymphoid Activation Antigene ACT35

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
(Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.

Biological Process

Biological Process immune response Source:ProtInc1 Publication
Biological Process inflammatory response Source:GO_Central1 Publication
Biological Process negative regulation of DNA-binding transcription factor activity Source:BHF-UCL
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL
Biological Process positive regulation of B cell proliferation Source:BHF-UCL
Biological Process positive regulation of immunoglobulin production Source:BHF-UCL
Biological Process T cell proliferation Source:BHF-UCL

Cellular Location

Membrane

Involvement in disease

Immunodeficiency 16 (IMD16):
An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency.

Topology

Extracellular: 29-214
Helical: 215-235
Cytoplasmic: 236-277

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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