Rabbit Anti-TNFSF15 Recombinant Antibody (D1C8W) (CBMAB-CP2812-LY)

Name: Rabbit Anti-TNFSF15 Recombinant Antibody (D1C8W)
SKU: CBMAB-CP2812-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

D1C8W

Application

Immunogen

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu88 of human TNFSF15 protein.

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

100 µg/ml BSA, 50% glycerol

Preservative

0.02% sodium azide

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TNFSF15 Gene(Protein Coding) TNF Superfamily Member 15

Introduction

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Entrez Gene ID

9966

UniProt ID

O95150

Alternative Names

TNF Superfamily Member 15; Vascular Endothelial Cell Growth Inhibitor; TNF Ligand-Related Molecule 1; Tumor Necrosis Factor (Ligand) Superfamily; Member 15; Vascular Endothelial Growth Inhibitor-192A; TNF Superfamily Ligand TL1A; VEGI; TL1;

Function

Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.

Biological Process

Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication

Cellular Location

Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted

Topology

Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TNFSF15 Matched Antibody Pair (1242) (CAT#: APMAB-1242LY)

TNFSF15 Matched Antibody Pair (1243) (CAT#: APMAB-1243LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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