TNFSF15
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Full Name
TNFSF15 Gene(Protein Coding) TNF Superfamily Member 15
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251
Helical: 36-56
Extracellular: 57-251
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Anti-TNFSF15 antibodies
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CompareTarget: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: VEGI/1283
Application*: WB, P, IF/IC, F
Target: TNFSF15
Specificity: Human
Target: TNFSF15
Specificity: Human
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3-12D11G
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4-3H8B
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1-8F-7G
Application*: WB
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1C8W
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C2
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A4
Application*: E, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E8
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E3
Application*: E, E
Target: Tnfsf15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3969
Application*: E, IP, WB
Target: Tnfsf15
Host: Hamster
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3968
Application*: E, F, FN
Target: Tnfsf15
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3967
Application*: N, WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBYJT-3966
Application*: F
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Laety-1
Application*: IP, WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TLRM1-1
Application*: WB, P, IF, IC, F
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3965
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3964
Application*: E, F
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3959
Application*: E, WB
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3958
Application*: WB, IH, N
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3957
Application*: WB, B, N
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3955
Application*: E, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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