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TNFSF15

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Full Name
TNFSF15 Gene(Protein Coding) TNF Superfamily Member 15
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251

Anti-TNFSF15 antibodies

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Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3955
Application*: E, WB
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3957
Application*: WB, B, N
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3958
Application*: WB, IH, N
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3959
Application*: E, WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3964
Application*: E, F
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3965
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: TLRM1-1
Application*: WB, P, IF, IC, F
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: Laety-1
Application*: IP, WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: CBYJT-3966
Application*: F
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E3
Application*: E, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1E8
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A4
Application*: E, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C2
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2H3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3D3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3H3
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F1
Application*: WB, E
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F3
Application*: WB, E
Target: TNFSF15
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D1C8W
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: VEGI/1283
Application*: WB, P, IF/IC, F
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1-8F-7G
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 4-3H8B
Application*: WB
Target: TNFSF15
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3-12D11G
Application*: WB
Target: Tnfsf15
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3969
Application*: E, IP, WB
Target: Tnfsf15
Host: Hamster
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYJT-3968
Application*: E, F, FN
Target: Tnfsf15
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3967
Application*: N, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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