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Mouse Anti-TNFSF15 Recombinant Antibody (VEGI/1283) (CBMAB-V0278-LY)

This product is antibody recognizes TNFSF15. The antibody VEGI/1283 immunoassay techniques such as: WB, IHC-P, IF/ICC, FC.
See all TNFSF15 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
VEGI/1283
Antibody Isotype
IgG1, к
Application
WB, IHC-P, IF/ICC, FC

Basic Information

Immunogen
A full length human recombinant protein was used as the immunogen for this TL1A antibody
Specificity
Human
Antibody Isotype
IgG1, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1 mg/mL BSA
Preservative
0.05% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TNFSF15 Gene(Protein Coding) TNF Superfamily Member 15
Introduction
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Entrez Gene ID
9966
UniProt ID
O95150
Alternative Names
TNF Superfamily Member 15; Vascular Endothelial Cell Growth Inhibitor; TNF Ligand-Related Molecule 1; Tumor Necrosis Factor (Ligand) Superfamily, Member 15; Vascular Endothelial Growth Inhibitor-192A; TNF Superfamily Ligand TL1A; VEGI; TL1;
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Biological Process
Biological Process activation of cysteine-type endopeptidase activity involved in apoptotic process Source:MGI1 Publication
Biological Process activation of NF-kappaB-inducing kinase activity Source:MGI1 Publication
Biological Process apoptotic process Source:InterPro
Biological Process immune response Source:InterPro
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Membrane
Tumor necrosis factor ligand superfamily member 15, secreted form
Secreted
Topology
Cytoplasmic: 1-35
Helical: 36-56
Extracellular: 57-251
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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