Mouse Anti-TNFSF18 Recombinant Antibody (1D12) (CBMAB-A9372-LY)

Name: Mouse Anti-TNFSF18 Recombinant Antibody (1D12)
SKU: CBMAB-A9372-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

1D12

Application

WB, ELISA

Immunogen

TNFSF18 (NP_005083, 68 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18

Introduction

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq]

Entrez Gene ID

8995

UniProt ID

Q9UNG2

Alternative Names

AITRL; GITRL; MGC138237; TL6; hGITRL

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

TNFSF18 Matched Antibody Pair (1244) (CAT#: APMAB-1244LY)

TNFSF18 Matched Antibody Pair (1245) (CAT#: APMAB-1245LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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