TNFSF18

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
Full Name
TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18
Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177
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Anti-TNFSF18 antibodies

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Rat Anti-TNFSF18 Recombinant Antibody (MIH44) (CBMAB-G1212-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: MIH44
Application*: F
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (721926) (CBMAB-G1211-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 721926
Application*: WB
Datasheet SDS

TNFSF18 Matched Antibody Pair (1245) (APMAB-1245LY)

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Target: TNFSF18
Specificity: Human
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TNFSF18 Matched Antibody Pair (1244) (APMAB-1244LY)

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Target: TNFSF18
Specificity: Human
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Mouse Anti-TNFSF18 Recombinant Antibody (6F7) (CBMAB-A9381-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F7
Application*: E, E
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (3A4) (CBMAB-A9374-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A4
Application*: E, E
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (2B8) (CBMAB-A9373-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B8
Application*: WB, E
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (1D12) (CBMAB-A9372-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D12
Application*: WB, E
Datasheet SDS

Rat Anti-Tnfsf18 Recombinant Antibody (CBYJT-3987) (CBMAB-T3399-YJ)

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Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3987
Application*: E, F, WB
Datasheet SDS

Rat Anti-Tnfsf18 Recombinant Antibody (CBYJT-3986) (CBMAB-T3398-YJ)

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Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3986
Application*: E, F
Datasheet SDS

Rat Anti-Tnfsf18 Recombinant Antibody (CBYJT-3985) (CBMAB-T3397-YJ)

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Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Mouse
Clone: CBYJT-3985
Application*: F, IP
Datasheet SDS

Rat Anti-Tnfsf18 Recombinant Antibody (CBYJT-3984) (CBMAB-T3396-YJ)

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Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3984
Application*: E, N
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3982) (CBMAB-T3394-YJ)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3982
Application*: E, WB
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3981) (CBMAB-T3393-YJ)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3981
Application*: F, N
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3978) (CBMAB-T3390-YJ)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3978
Application*: E, WB
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3971) (CBMAB-T3383-YJ)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3971
Application*: F, N
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3970) (CBMAB-T3382-YJ)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3970
Application*: F
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (6D416) (CBMAB-G6652-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D416
Application*: E, WB
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (6D415) (CBMAB-G6651-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D415
Application*: E, F
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (4Q25) (CBMAB-G6650-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4Q25
Application*: F
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (12D23) (CBMAB-G6649-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 12D23
Application*: E, N
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (YGL386) (CBMAB-G1215-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: YGL386
Application*: F
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (5F1) (CBMAB-G1210-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5F1
Application*: F
Datasheet SDS

Rat Anti-TNFSF18 Recombinant Antibody (337122) (CBMAB-G1209-LY)

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Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 337122
Application*: N, EC
Functional Assay
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (109114) (CBMAB-G1208-LY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 109114
Application*: F
Datasheet SDS

Mouse Anti-TNFSF18 Recombinant Antibody (CBFYH-2805) (CBMAB-H3869-FY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2805
Application*: E
Datasheet SDS

Human Anti-TNFSF18 Recombinant Antibody (CBFYH-2804) (CBMAB-H3868-FY)

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Target: TNFSF18
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2804
Application*: F
Datasheet SDS

Mouse Anti-TNFSF18 Monoclonal Antibody (CBFYH-3314) (CBMAB-H0762-FY)

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Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3314
Application*: F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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