TNFSF18
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]
Full Name
TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18
Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177
Helical: 28-48
Extracellular: 49-177
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Anti-TNFSF18 antibodies
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CompareTarget: TNFSF18
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: MIH44
Application*: F
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 721926
Application*: WB
Target: TNFSF18
Specificity: Human
Target: TNFSF18
Specificity: Human
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6F7
Application*: E, E
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3A4
Application*: E, E
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2B8
Application*: WB, E
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D12
Application*: WB, E
Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3987
Application*: E, F, WB
Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBYJT-3986
Application*: E, F
Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2b, λ
Specificity: Mouse
Clone: CBYJT-3985
Application*: F, IP
Target: Tnfsf18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBYJT-3984
Application*: E, N
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-3982
Application*: E, WB
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3981
Application*: F, N
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJT-3978
Application*: E, WB
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3971
Application*: F, N
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3970
Application*: F
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D416
Application*: E, WB
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 6D415
Application*: E, F
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4Q25
Application*: F
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: 12D23
Application*: E, N
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: YGL386
Application*: F
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5F1
Application*: F
Target: TNFSF18
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 337122
Application*: N, EC
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 109114
Application*: F
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2805
Application*: E
Target: TNFSF18
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2804
Application*: F
Target: TNFSF18
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3314
Application*: F
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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