Human Recombinant TNFSF18 protein, Biotin Conjugated, AVI & Fc Tag (V2LY-0526-LY4315)

Name: Human Recombinant TNFSF18 protein, Biotin Conjugated, AVI & Fc Tag
SKU: V2LY-0526-LY4315
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

AVI & Fc Tag

Protein Construction

This product is Human Recombinant TNFSF18 protein, Biotin Conjugated, AVI & Fc Tag consist of Amino Acid: 50-177 and predicts a molecular mass of 42.38 kDa.

Molecule Mass

42.38 kDa

Verified

HPLC

Conjugates

Biotin

Sequence

Amino Acid: 50-177

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE. ≥90% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18

Function

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).

Biological Process

Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB

Cellular Location

Cell membrane

Topology

Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant TNFSF18 protein, ECD, Fc Tag (CAT#: V2LY-0526-LY4316)

Human Recombinant TNFSF18 protein, His Tag (CAT#: V2LY-0526-LY4317)

TNFSF18 Matched Antibody Pair (1244) (CAT#: APMAB-1244LY)

TNFSF18 Matched Antibody Pair (1245) (CAT#: APMAB-1245LY)

Antibody Pairs

TNFSF18 Matched Antibody Pair (1244) (CAT#: APMAB-1244LY)

TNFSF18 Matched Antibody Pair (1245) (CAT#: APMAB-1245LY)

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TNFSF18 Matched Antibody Pair (1245) (CAT#: APMAB-1245LY)

Rat Anti-TNFSF18 Recombinant Antibody (MIH44) (CAT#: CBMAB-G1212-LY)

Mouse Anti-TNFSF18 Recombinant Antibody (CBFYH-2805) (CAT#: CBMAB-H3869-FY)

Rat Anti-TNFSF18 Recombinant Antibody (6D416) (CAT#: CBMAB-G6652-LY)

Rat Anti-TNFSF18 Recombinant Antibody (6D415) (CAT#: CBMAB-G6651-LY)

Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3978) (CAT#: CBMAB-T3390-YJ)

Human Recombinant TNFSF18 protein, His Tag (CAT#: V2LY-0526-LY4317)

Mouse Anti-TNFSF18 Recombinant Antibody (4Q25) (CAT#: CBMAB-G6650-LY)

Mouse Anti-TNFSF18 Recombinant Antibody (1D12) (CAT#: CBMAB-A9372-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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