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Mouse Anti-TNNC1 Recombinant Antibody (CBYJT-4055) (CBMAB-T3471-YJ)

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Basic Information

Host Animal
Mouse
Clone
CBYJT-4055
Application
ELISA, WB, IHC
Immunogen
GST fusion protein corresponding to aa74-282 of the mature form of human gamma C1qR. The epitope has been mapped to aa204-218
Specificity
Human, Cattle, Cat, Dog, Fish, Goat, Mouse, Pig, Rabbit, Rat
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 74-282
More Infomation

Target

Full Name
troponin C type 1 (slow)
Introduction
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TNNC1 (TnC), the protein encoded by this gene. The binding of calcium to TNNC1 (TnC) abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.
Entrez Gene ID
Human7134
Mouse21924
Rat290561
Cattle509486
Cat101082986
Dog476595
Goat100860954
Pig100156435
Rabbit100347570
UniProt ID
HumanP63316
MouseP19123
RatQ4PP99
CattleP63315
CatM3WN51
GoatF6KVT2
DogA0A8C0REA5
PigP63317
RabbitP02591
Alternative Names
Troponin C1, Slow Skeletal And Cardiac Type; Troponin C Type 1 (Slow); TN-C; TNNC; Slow Twitch Skeletal/Cardiac Muscle Troponin C; Troponin C, Slow Skeletal And Cardiac Muscles
Function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Biological Process
Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process diaphragm contraction Source:Ensembl
Biological Process regulation of ATP-dependent activity Source:BHF-UCL
Biological Process regulation of muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of muscle filament sliding speed Source:BHF-UCL
Biological Process response to metal ion Source:Ensembl
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Cellular Location
cardiac Troponin complex
cytosol
troponin complex
Involvement in disease
Cardiomyopathy, dilated 1Z (CMD1Z):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 13 (CMH13):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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