TNNC1
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq]
Full Name
troponin C type 1 (slow)
Function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Biological Process
Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process diaphragm contraction Source:Ensembl
Biological Process regulation of ATP-dependent activity Source:BHF-UCL
Biological Process regulation of muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of muscle filament sliding speed Source:BHF-UCL
Biological Process response to metal ion Source:Ensembl
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Biological Process diaphragm contraction Source:Ensembl
Biological Process regulation of ATP-dependent activity Source:BHF-UCL
Biological Process regulation of muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of muscle filament sliding speed Source:BHF-UCL
Biological Process response to metal ion Source:Ensembl
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Cellular Location
cardiac Troponin complex
cytosol
troponin complex
cytosol
troponin complex
Involvement in disease
Cardiomyopathy, dilated 1Z (CMD1Z):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 13 (CMH13):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 13 (CMH13):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
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Anti-TNNC1 antibodies
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CompareTarget: TNNC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F8-A9
Application*: WB, E
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: n.a
Application*: E, P, WB
Target: TNNC1
Host: Mouse
Specificity: Rat
Clone: CBCNC-717
Application*: WB, ICC, P, IH-F, E
Target: TNNC1
Host: Mouse
Specificity: Human
Clone: CBCNC-716
Application*: WB, ICC, P, IH-F, E
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBCNC-715
Application*: E, P, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B204
Application*: E, IH, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Cattle, Cat, Dog, Fish, Goat, Mouse, Pig, Rabbit, Rat
Clone: CBYJT-4055
Application*: E, WB, IH
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4054
Application*: P, WB, E
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4053
Application*: IH
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4051
Application*: E, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4050
Application*: IH
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4049
Application*: WB, IH
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4048
Application*: E, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4047
Application*: WB, IO, SE
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4046
Application*: IH
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-4045
Application*: E, WB, P
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-4042
Application*: E, IH, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-4041
Application*: E, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-3195
Application*: E, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3194
Application*: E, IA, WB
Target: TNNC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A10A12
Application*: WB, E, P, C
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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