Mouse Anti-TNNC1 Recombinant Antibody (CBYJT-4050) (CBMAB-T3466-YJ)

Name: Mouse Anti-TNNC1 Recombinant Antibody (CBYJT-4050)
SKU: CBMAB-T3466-YJ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYJT-4050

Application

IHC

Immunogen

Full length human recombinant protein of human TNNC1 (NP_003271) produced in E. coli

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer

PBS, pH 7.3, 1% BSA, 50% Glycerol

Preservative

0.02% Sodium Azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

troponin C type 1 (slow)

Introduction

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TNNC1 (TnC), the protein encoded by this gene. The binding of calcium to TNNC1 (TnC) abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z.

Entrez Gene ID

7134

UniProt ID

P63316

Alternative Names

Troponin C1, Slow Skeletal And Cardiac Type; Troponin C Type 1 (Slow); TN-C; TNNC; Slow Twitch Skeletal/Cardiac Muscle Troponin C; Troponin C, Slow Skeletal And Cardiac Muscles

Function

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Biological Process

Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process diaphragm contraction Source:Ensembl
Biological Process regulation of ATP-dependent activity Source:BHF-UCL
Biological Process regulation of muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of muscle filament sliding speed Source:BHF-UCL
Biological Process response to metal ion Source:Ensembl
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication

Cellular Location

cardiac Troponin complex
cytosol
troponin complex

Involvement in disease

Cardiomyopathy, dilated 1Z (CMD1Z):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 13 (CMH13):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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