Sign in or Register   Sign in or Register
  |  

Mouse Anti-TNNC1 Recombinant Antibody (n.a) (CBMAB-C12607-LY)

The product is antibody recognizes TNNC1. The antibody n.a immunoassay techniques such as: ELISA, IHC-P, WB.
See all TNNC1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
n.a
Antibody Isotype
IgG2a
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
troponin C type 1 (slow)
Introduction
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Entrez Gene ID
7134
UniProt ID
P63316
Alternative Names
Troponin C1, Slow Skeletal And Cardiac Type; Troponin C Type 1 (Slow); TN-C; TNNC; Slow Twitch Skeletal/Cardiac Muscle Troponin C; Troponin C, Slow Skeletal And Cardiac Muscles;
Function
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
Biological Process
Biological Process cardiac muscle contraction Source:CAFA1 Publication
Biological Process diaphragm contraction Source:Ensembl
Biological Process regulation of ATP-dependent activity Source:BHF-UCL
Biological Process regulation of muscle contraction Source:BHF-UCL1 Publication
Biological Process regulation of muscle filament sliding speed Source:BHF-UCL
Biological Process response to metal ion Source:Ensembl
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:BHF-UCL1 Publication
Cellular Location
cardiac Troponin complex
cytosol
troponin complex
Involvement in disease
Cardiomyopathy, dilated 1Z (CMD1Z):
A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Cardiomyopathy, familial hypertrophic 13 (CMH13):
A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TNNC1 Recombinant Antibody (n.a)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare