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Mouse Anti-TNNI1 Recombinant Antibody (4G6) (CBMAB-A9399-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4G6
Antibody Isotype
IgG2b, κ
Application
sELISA, ELISA

Basic Information

Immunogen
TNNI1 (AAH12601, 1 a.a. ~ 187 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
troponin I type 1 (skeletal, slow)
Introduction
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq]
Entrez Gene ID
7135
UniProt ID
P19237
Alternative Names
DKFZp451O223; SSTNI; TNN1
Function
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Biological Process
Biological Process cardiac muscle contraction Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process regulation of striated muscle contraction Source:UniProtKB1 Publication
Biological Process skeletal muscle contraction Source:GO_Central1 Publication
Biological Process transition between fast and slow fiber Source:Ensembl
Biological Process ventricular cardiac muscle tissue morphogenesis Source:Ensembl
Cellular Location
cytosol
troponin complex
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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